Synthesis, Characterization, Anti-Glycation, and Anti-Oxidant Activities of Sulfanilamide Schiff Base Metal Chelates

Abstract

The current study reports synthesis, structure establishment, anti-glycation, and anti-oxidant activities of ligand 4-[(2-hydroxynaphthalene-1-ylmethylene)-amino]-benzenesulfonamide (L) and its coordination compounds with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) metal ions. The analytical techniques used (UV-Vis, FT-IR, CHN/S) confirmed the bidentate nature of the ligand, coordinating via O and N atoms in 2:1 ligand-to-metal ratio. The TG/DTA anylsis displayed that these compounds are thermally stable. Furthermore, the synthesized compounds were evaluated for their anti-glycation and antioxidant potential and showed significant activities with IC₅₀ values range 184.11–386.34 µM and 37.05–126.27 µM, respectively. The Mn (IC₅₀ = 184.11 ± 2.11 µM), Ni (IC₅₀ = 211.26 ± 1.46 µM), Cu (IC₅₀ = 254.56 ± 1.16 µM), and Zn (IC₅₀ = 276.43 ± 2.14 µM) metal complexes exhibited substantial anti-glycation activity and comparatively better activity than the standard rutin (IC₅₀ = 294.4 ± 1.50 µM), whereas Zn complex (IC₅₀ = 37.05 ± 1.53 μM) also showed better DPPH radical scavenging activity than the standard tert-butyl-4-hydroxyanisole (IC₅₀ = 44.7 ± 1.21 µM).