Metal Based Bioactive Nitrogen and Oxygen Donor Mono and Bis Schiff Bases: Design, Synthesis, Spectral Characterization, Computational Analysis and Antibacterial Screening

Authors

  • Sajjad Hussain Sumrra Department of Chemistry, University of Gujrat, Gujrat, Pakistan
  • Wardha Zafar Department of Chemistry, University of Gujrat, Gujrat, Pakistan
  • Sabaahatul Ain Malik Department of Chemistry, University of Gujrat, Gujrat, Pakistan
  • Khalid Mahmood Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan
  • Syed Salman Shafqat Department of Chemistry, Division of Science and Technology, University of Education, Lahore, Pakistan
  • Saira Arif Department of Chemistry, University of Gujrat, Gujrat, Pakistan

DOI:

https://doi.org/10.17344/acsi.2021.7182

Keywords:

Symmetrical phenylenediamine mono and bis-Schiff bases, computational study, chelation, bidentate and tetradentate, antibacterial activity

Abstract

The scientific interest in developing the advanced metal based compounds to inhibit and control bacterial infections is continuously rising. Keeping in view their pharmacological significance, two new bioactive symmetrical phenylenediamine mono- and bis-Schiff bases, 2-{[(4-aminophenyl)imino]methyl}-6-methoxyphenol (L1) and 2,2'-{benzene-1,2-diylbis[nitrilomethylylidene]}bis(6-methoxyphenol) (L2) have been synthesized and characterized by using physical techniques, spectral methods, elemental and DFT based computational analysis with B3LYP/6-311++G(d, p) basis set. Furthermore, the synthesized ligands were complexed with VO, Mn, Co, Ni, Cu and Zn ions in ratio [M:L,1:2 and 1:1], respectively. All the complexes exhibited significant antibacterial action against all tested bacterial strains. But overall, the zinc complexes possessed higher antibacterial activity. These results concluded that metal complexes might be promising induction in the upcoming time for medical purposes.

Author Biography

Sajjad Hussain Sumrra, Department of Chemistry, University of Gujrat, Gujrat, Pakistan

Tenured Associate Professor

Department of Chemistry

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Published

15.03.2022

Issue

Vol. 69 No. 1 (2022)

Section

Inorganic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License