Investigation of Biological and Prooxidant Activity of Zinc Oxide Nanoclusters and Nanoparticles

Authors

  • Iliana A. Ivanova Dept. Microbiology, Faculty of Biology, Sofia University Saint Kliment Ohridski, 8 Dragan Tsankov Blvd, 1164 Sofia, Bulgaria
  • Elitsa L. Pavlova Faculty of Physics, Sofia University“St. Kliment Ohridski”, 5 James Bourchier Blvd., 1164 Sofia, Bulgaria
  • Anelyia s. Kostadinova Institute of biophysics and biomedical engineering, Bulgarian academy of science, Akad. Georgi Bonchev 21str, Sofia 1113, Bulgaria
  • Radostina D. Toshkovska Institute of Organic Chemistry with Center of Phytochemistry, 9 Acad. G. Bonchev Str, Sofia
  • lLyubomira D. Yocheva Faculty of Medicine, Sofia University“St. Kliment Ohridski”, 1 Kozyak Str, 1407, Sofia, Bulgaria
  • kh. El-Sayed Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Giza, Egypt
  • Mohamed A. Hassan Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Giza, Egypt
  • Heba Elsayed ElZorkany Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Giza, Egypt
  • Hisham Ali Elshoky Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center. http://orcid.org/0000-0003-2105-1600

DOI:

https://doi.org/10.17344/acsi.2021.7337

Keywords:

ZnO, Nanoclusters, nanocomposites, antimicrobial activity, ROS, chemiluminescence.

Abstract

Zinc oxide (ZnO) nanomaterials offer some promising antibacterial effects. In this study, a new form of ZnO is synthesized, named ZnO nanocluster bars (NCs). Herein, ZnO NCs, ZnO nanoparticles (NPs), ZnO coated with silica (ZnO-SiOA, ZnO-SiOB), and SiO2 NPs were prepared, characterized, and their antimicrobial and prooxidant activity were tested. The prooxidant activity of all nanomaterials was studied according to free-radical oxidation reactions (pH 7.4 and pH 8.5) in chemiluminescent model systems. Each form of new synthesized ZnO nanomaterials exhibited a unique behavior that varied from mild to strong prooxidant properties in the Fenton`s system. ZnO NPs and ZnO NCs showed strong antibacterial effects, ZnO-SiOA NPs did not show any antibacterial activity representing biocompatibility. All tested NMs also underwent oxidation by H2O2. ZnO NCs and ZnO NPs exhibited strong oxidation at pH 8.5 in the O2-. generating system. While, SiO2, ZnO-SiOA andZnO-SiOB possessed pronounced 60-80% antioxidant effects, SiO2 NPs acted as a definitive prooxidant which was not observed in other tests. ZnO NCs are strong oxidized, assuming that ZnO NCs provide a slower release of ZnO, which leads to having a stronger effect on bacterial strains.  Thus, ZnO NCs are an important antibacterial agent that could be an emergent replacement of traditional antibiotics.

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Published

26.09.2022

Issue

Vol. 69 No. 3 (2022)

Section

Materials science

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License