Interactions between Ibuprofen and Silicified-MCC: Characterization, Drug Release and Modeling Approaches

Authors

  • Rudra Narayan Sahoo
  • Ashirbad Nanda
  • Arunima Pramanik
  • Souvik Nandi
  • Rakesh Swain
  • Sukanta Kumar Pradhan
  • Subrata Mallick School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University)

DOI:

https://doi.org/10.17344/acsi.2019.5139

Keywords:

Co-processing, silicified microcrystalline cellulose, Docking analysis, Binary interaction, Ternary interaction.

Abstract

Analysis of the binding interactions of ibuprofen and silicified-microcrystalline cellulose (SMCC) has been undertaken. Co-processing of ibuprofen with SMCC was carried out by solid state ball milling, and aqueous state equilibration followed by freeze drying to investigate the effect of silicified-microcrystalline cellulose on ligand. Molecular docking study revealed that ibuprofen formed complex through hydrogen bond with microcrystalline cellulose (MCC) and silicon dioxide (SiO2); the binding energy between MCC and SiO2, and ibuprofen and SMCC were found as -1.11 and -1.73 kcal/mol respectively. The hydrogen bond lengths were varying from 2.028 to 2.056 Å. Interaction of Si atom of SMCC molecule with Pi-Orbital of ibuprofen has shown the bond length of 4.263 Å. Significant improvement in dissolution of ibuprofen has been observed as a result of interaction. Binary and ternary interactions revealed more stabilizing interactions with ibuprofen and SMCC compared to SMCC formation.

Author Biography

Subrata Mallick, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University)

Professor,

Pharmaceutical Sciences

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Published

18.12.2019

Issue

Vol. 66 No. 4 (2019)

Section

Materials science

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License