Synthesis and Characterization of Tetrachloro-1,3-Oxazepine Derivatives and Evaluation of Their Biological Activities

Abstract

6,7,8,9-Tetrachloro[1,3]oxazepine-1,5-dione derivatives 1b–10b have been synthesized by reacting Schiff bases 1a–10a with tetrachlorophthalic anhydride (TCPA) under (2 + 5 → 7) cycloaddition reaction conditons. All reactions had been monitored using TLC. FT IR and melting points have been used to characterize the Schiff bases; oxazepine compounds 1b–10b were characterized using FT IR, ¹H NMR and their melting points. Biological activity for oxazepine compounds has been evaluated against bacterial types (Staphylococcus aureus, Escherichia coli, Klebsiella spp.) and against a fungus (Geotrichum spp.). Variable activities have been observed against used strains of bacteria and fungi.