Synthesis, Characterization and Cytotoxicity Evaluation of New Biimidazole Palladium(II) Complexes with Thioureas

Authors

  • Silmar José Spinardi Franchi UFSC – Federal University of Santa Catarina, Departamento de Ciências Exatas e Educação, 89036-256, Blumenau, SC, Brazil
  • Rodrigo Alves de Souza UNESP – Sao Paulo State University, Instituto de Química de Araraquara, C.P. 355, 14800-900, Araraquara, SP, Brazil
  • Antonio Eduardo Mauro UNESP – Sao Paulo State University, Instituto de Química de Araraquara, C.P. 355, 14800-900, Araraquara, SP, Brazil
  • Iracilda Zeppone Carlos UNESP – Sao Paulo State University, Faculdade de Ciências Farmacêuticas, 14801-902, Araraquara, SP, Brazil
  • Livia Carolina de Abreu Ribeiro UNESP – Sao Paulo State University, Faculdade de Ciências Farmacêuticas, 14801-902, Araraquara, SP, Brazil
  • Fillipe Vieira Rocha UFSCar – Federal University of São Carlos, Departamento de Química, 13565-905, São Carlos, SP, Brazil
  • Adelino Vieira de Godoy-Netto UNESP – Sao Paulo State University, Instituto de Química de Araraquara, C.P. 355, 14800-900, Araraquara, SP, Brazil

DOI:

https://doi.org/10.17344/acsi.2017.4112

Keywords:

Palladium(II), 2, 2'-bis(4, 5-dimethylimidazole), thioureas, cytotoxicity, cancer

Abstract

The reactions between [PdCl2(tmbiimH2)]·H2O (1) {tmbiimH2 = 2,2'-bis(4,5-dimethylimidazole)} and thiourea (tu), N-methylthiourea (mtu), N-phenylthiourea (ptu), N,N’-dimethylthiourea (dmtu) or N,N’-diphenylthiourea (dptu) in the 1:2 molar ratio resulted in the compounds [PdL2(tmbiimH2)]Cl2·nH2O {L = tu (2), mtu (3), ptu (4), dmtu (5) and dptu (6)}, which were characterized by elemental analyses, infrared (IR), and 1H NMR spectroscopies and conductivity measurements. The IR spectra of 1–6 were consistent with the presence of chelating tmbimH2 ligand. All compounds and cisplatin were tested in vitro by MTT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3), lung adenocarcinoma (LP07) and mouse fibroblast (L929) cells. Relating the series of compounds to their biological activities we found compound 6 as the most promising of them.

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Published

17.09.2018

Issue

Vol. 65 No. 3 (2018)

Section

Inorganic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License