Synthesis and X-ray Structural Analysis of the Ruthenium(III) Complex Na[trans-RuCl4(DMSO)(PyrDiaz)], the Diazene Derivative of Antitumor NAMI-Pyr

Jure Vajs; Andrej Pevec; Martin Gazvoda; Damijana Urankar; Evgeny Goreshnik; Slovenko Polanc; Janez Košmrlj

doi:10.17344/acsi.2017.3844

Synthesis and X-ray Structural Analysis of the Ruthenium(III) Complex Na[trans-RuCl4(DMSO)(PyrDiaz)], the Diazene Derivative of Antitumor NAMI-Pyr

Authors

Jure Vajs
Andrej Pevec
Martin Gazvoda
Damijana Urankar
Evgeny Goreshnik
Slovenko Polanc
Janez Košmrlj University of Ljubljana

DOI:

https://doi.org/10.17344/acsi.2017.3844

Keywords:

diazene, pyridine, ruthenium(III), sodium, polynuclear complex, polymeric complex

Abstract

Novel tetrachloridoruthenium(III) complex Na[trans-RuCl₄(DMSO)(PyrDiaz)] (3) with pyridine-tethered diazenedicarboxamide PyrDiaz ligand (PyrDiaz = N¹-(4-isopropylphenyl)-N²-(pyridin-2-ylmethyl)diazene-1,2-dicarboxamide) was synthesized by direct coupling of PyrDiaz with sodium trans-bis(dimethyl sulfoxide)tetrachloridoruthenate(III) (Na-[trans-Ru(DMSO)₂Cl₄]). Compound 3 is the analogue of the antimetastatic Ru(III) complex NAMI-A and NAMI-Pyr. Single crystal X-ray diffraction analysis revealed that the compound 3 is a polymeric complex with the ruthenium and sodium centres.

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Published

12.12.2017

Issue

Vol. 64 No. 4 (2017): Acsi

Section

Organic chemistry

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