Aaptamine, Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers, Isolated from the Bunaken National Park’s Sponge, Aaptos sp.

Aaptamine Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

Abstract

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising discovery of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC₅₀ values of 30.3 and 236.8 µg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and relatively induce necrotic cell death.