Syntheses, Characterization and Crystal Structures of Dicyanamide Bridged Polynuclear Copper(II) and Zinc(II) Complexes with Urease Inhibitory Activity

Authors

  • Li Zhang
  • Yuqing Gu
  • Xinhui Feng
  • Ting Yang
  • Xiaoyan Li
  • Jing Wang
  • Zhonglu You Liaoning Normal University

DOI:

https://doi.org/10.17344/acsi.2022.7578

Keywords:

Schiff base, copper and zinc complexes, crystal structure, urease inhibition

Abstract

A pair of structurally similar dicyanamide bridged copper(II) and zinc(II) complexes [CuL(dca)]n (1) and [ZnL(dca)]n (2), were prepared from the fluorine containing Schiff base 5-fluoro-2-(((2-hydroxyethyl)imino)methyl)phenol (HL). The compounds were characterized by physico-chemical methods. Structures of the complexes were confirmed by single crystal X-ray diffraction. The Cu atom in complex 1 is in square pyramidal coordination, whereas the Zn atom in complex 2 is in trigonal bipyramidal coordination. The copper complex has effective Jack bean urease inhibitory activity, with IC50 value of 0.14±0.12 μmol L–1.

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Published

26.09.2022

Issue

Vol. 69 No. 3 (2022)

Section

Inorganic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License