Enantioselective Henry Reaction Catalyzed by Chiral Piperazine Derivatives

Authors

  • Leman Alkan Ege University

DOI:

https://doi.org/10.17344/acsi.2021.7150

Keywords:

Piperazine, Schiff base, chiral catalyst, enantioselective Henry reaction

Abstract

A series of novel tridentate Schiff bases is synthesized from piperazine-amine and substituted salicylaldehydes, and characterized by spectroscopic methods. These chiral ligands were used to catalyze the addition of nitromethane to various aldehydes in the presence of Cu(II) ions under ambient conditions in good yields (98%) and high enantioselectivities (9:91 er).

Author Biography

Leman Alkan, Ege University

Chemistry Department

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Published

14.06.2022

Issue

Vol. 69 No. 2 (2022)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License