Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine

Authors

  • Amira E. M. Abdallah Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt http://orcid.org/0000-0002-6773-3634
  • Rafat M. Mohareb Department of Chemistry, Faculty of Science, Cairo University, Giza, A. R. Egypt http://orcid.org/0000-0001-6529-0043
  • Maher H. E. Helal Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt
  • Germeen J. Mofeed Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt

DOI:

https://doi.org/10.17344/acsi.2020.6446

Keywords:

anticancer, chromene, 4-phenylthiazol-2-amine, pyridine, pyrimidine, thiophene

Abstract

Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chemical reagents was studied. The structure of the newly synthesized compounds was established based on elemental analysis and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (µM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds 9 and 14a displayed higher effeciency than the reference doxorubicin.

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Published

15.09.2021

Issue

Vol. 68 No. 3 (2021)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License