Synthesis, Characterization, X-Ray Crystal Structures and Antibacterial Activities of Oxidovanadium(V) Complexes with Hydrazone and Hydroxamate Ligands

Abstract

Two new oxidovanadium(V) complexes, [VOL¹L] (1) and [VOL²L]·CH₃OH (2·CH₃OH), where L¹ and L² are the dianionic form of N’-(3-bromo-2-hydroxybenzylidene)picolinohydrazide (H₂L¹) and 2-chloro-N’-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (H₂L²), respectively, and L is the monoanionic form of 2-hydroxybenzohydroxamic acid (HL), were prepared and characterized by elemental analysis, infrared and electronic spectroscopy. Structures of the complexes were further confirmed by single crystal X-ray determination. The V atoms in the complexes are in octahedral coordination. The hydrazone ligands coordinate to the V atoms through the phenolate O, imino N, and enolate O atoms. The hydroxamate ligand coordinates to the V atom through the carbonyl and hydroxy O atoms. The complexes show effective antibacterial activity against B. subtilis, S. aureus and E. coli. The presence of Cl substitute group in the complex may enhance the antibacterial activity.