Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters

Authors

  • Jelena S Lazarević Department of Chemistry, Faculty of Medicine, University of Niš
  • Ana Kolarević Department of Pharmacy, Faculty of Medicine, University of Niš
  • Gordana Stojanović Department of Chemistry, Faculty of Science and Mathematics, University of Niš
  • Andrija Šmelcerović Department of Chemistry, Faculty of Medicine, University of Niš
  • Pierangela Ciuffreda Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano
  • Enzo Santaniello Department of Biomedical Sciences, Humanitas University

DOI:

https://doi.org/10.17344/acsi.2018.4380

Keywords:

Chemical synthesis, eugenyl esters, in vitro antimicrobial activity, in silico calculation

Abstract

The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which are new compounds, is reported. All compounds were subjected to in vitro antimicrobial testing. In silico studies were carried out calculating physico-chemical, pharmacokinetic and toxicological properties, providing more data as additional guidance for further research.

Author Biographies

Jelena S Lazarević, Department of Chemistry, Faculty of Medicine, University of Niš

Department of Chemistry, assistant professor

Ana Kolarević, Department of Pharmacy, Faculty of Medicine, University of Niš

Department of Pharmacy, teaching assistant

Gordana Stojanović, Department of Chemistry, Faculty of Science and Mathematics, University of Niš

Department of Chemistry, full professor

Andrija Šmelcerović, Department of Chemistry, Faculty of Medicine, University of Niš

Department of Chemistry, associate professor

Pierangela Ciuffreda, Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", associate professor

Enzo Santaniello, Department of Biomedical Sciences, Humanitas University

Department of Biomedical Sciences, full professor

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Published

14.12.2018

Issue

Vol. 65 No. 4 (2018)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License