Copper(II) Schiff Base Complexes with Catalyst Property: Experimental, Theoretical, Thermodynamic and Biological Studies

Authors

  • Elham Zarenezhad Non‑communicable Diseases Research Center, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  • Sheida Esmaielzadeh Department of Chemistry, Darab branch, Islamic Azad University, Darab, I. R. Iran

DOI:

https://doi.org/10.17344/acsi.2018.4159

Keywords:

Copper complex, Catalytic activity, Antibacterial Screening, Formation constant, DFT calculations.

Abstract

Two novel copper(II) Schiff base complexes were synthesized and characterized by various physico-chemical and spectroscopic methods, revealing a distorted square planar geometry around the copper atom. The analytical data confirmed the 1:1 metal to ligand stoichiometry of the complexes. B3LYP/(LANL2DZ/6-311G**) density functional theory (DFT) were used to investigate structural and electronic properties of the synthesized compounds in gas phase. The computational results support the conclusion obtained by the experimental studies. Thermodynamic study of complex formation in solution was carried out spectrophotometrically at 25°C. These compounds were also subjected to study in vitro antibacterial screening against some bacteria. Also, click reaction was investigated for its catalytic properties. The synthesized Schiff base copper complexes catalyzed 1,3-dipolar Huisgen cycloaddition of different functionalized β-azido alcohols and alkynes in the presence of ascorbic acid in a solution of THF/H2O (2:1, V/V) at room temperature.

Author Biography

Sheida Esmaielzadeh, Department of Chemistry, Darab branch, Islamic Azad University, Darab, I. R. Iran

Department of Chemistry

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Published

19.06.2018

Issue

Vol. 65 No. 2 (2018)

Section

Inorganic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License