Voltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode

Authors

  • Ali Kamal Attia National Organization for Drug Control and Research (NODCAR)
  • Waheed M Salem
  • Mona A Mohamed

DOI:

https://doi.org/10.17344/acsi.2014.950

Keywords:

Metformin, Modified electrode, Voltammetry, Urine

Abstract

The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior at all pH values of Britton-Robinson buffer (2.0-9.0). The peak current varied linearly in the range comprised between 8.0 x 10-7 and 6.0 x 10-6 mol/Lwith detection limit of 6.63 x 10-8 mol/Land limit of quantification of 2.21 x 10-7 mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine.

Author Biography

Ali Kamal Attia, National Organization for Drug Control and Research (NODCAR)

Department of analytical chemistry,

National Organization for Drug Control and Research

 (NODCAR)

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Published

17.07.2015

Issue

Vol. 62 No. 3 (2015)

Section

Analytical chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License