Immunomodulatory Role of Palladium(II) Complex with Ethyl Derivative of Thiosalicylic Acid Ligand

Mirjana Jakovljević; Jovana Marinković; Dusan Tomović; Gordana Radić; Irfan Ćorović; Slađana Pavlović; Bojana Simović Marković; Ivan Jovanović; Andriana Bukonjić

doi:10.17344/acsi.2025.9301

Authors

Mirjana Jakovljević https://orcid.org/0009-0008-2762-1081
Jovana Marinković https://orcid.org/0009-0007-6203-6657
Dusan Tomović Faculty of Medical Sciences, University of Kragujevac https://orcid.org/0000-0001-8921-490X
Gordana Radić https://orcid.org/0000-0002-2526-1325
Irfan Ćorović https://orcid.org/0009-0006-4675-4344
Slađana Pavlović https://orcid.org/0000-0002-8912-1874
Bojana Simović Marković https://orcid.org/0000-0001-8408-4624
Ivan Jovanović https://orcid.org/0000-0002-1169-2378
Andriana Bukonjić https://orcid.org/0000-0003-3949-2930

DOI:

https://doi.org/10.17344/acsi.2025.9301

Abstract

Many complexes have shown antitumor potential, including the bis(S-ethyl-2-thiosalicylate)palladium(II) complex. The aim of this study was to investigate potential immunomodulatory effects of this complex on acquired and innate immunity, in vitro. The effect was assessed based on the levels of cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL) 1β, interferon gamma (IFN-γ), IL-17 and IL-10. Cytokine concentrations were measured by ELISA assay. Pd(II) complex led to a reduced secretion of most pro-inflammatory cytokines. The effects of the complex were more intense in non-activated cells. The same effect was shown in cells of acquired and innate immunity. These effects make the Pd(II) complex not only a potential antitumor agent, but also an anti-inflammatory agent.

Immunomodulatory Role of Palladium(II) Complex with Ethyl Derivative of Thiosalicylic Acid Ligand

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