Synthesis, Characterization and Crystal Structures of Aroylhydrazones Derived from 2-Chlorobenzaldehyde with Various Benzohydrazides

Abstract

Reaction of 2-chlorobenzaldehyde with 3-trifluoromethylbenzohydrazide, 3,5-dimethoxybenzohydrazide, 4-trifluoromethylbenzohydrazide and 2-bromobenzohydrazide, respectively, in methanol afforded four new aroylhydrazones. The newly synthesized compounds were characterized by means of elemental analysis, IR and ¹H NMR spectroscopy, and their structures were further confirmed by X-ray single crystal determination. The compounds were assayed for their antibacterial activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus and show interesting results.