Development of eutectics of pioglitazone with citric acid and its effect on crystallite properties and dissolution

Mouli Das; Shibashis Panigrahy; Rasmita Dash; Rudra Narayan Sahoo; Rakesh Swain; Souvik Nandi; Sk Habibullah; Tanisha Das; Subrata Mallick

doi:10.17344/acsi.2024.8793

Development of eutectics of pioglitazone with citric acid and its effect on crystallite properties and dissolution

Authors

Mouli Das
Shibashis Panigrahy
Rasmita Dash
Rudra Narayan Sahoo
Rakesh Swain
Souvik Nandi
Sk Habibullah
Tanisha Das
Subrata Mallick School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University)

DOI:

https://doi.org/10.17344/acsi.2024.8793

Abstract

Eutectics of pioglitazone were developed using citric acid (CA) as the co-former, and the effect on crystallite properties and dissolution has correspondingly been studied. Pioglitazone-citric acid eutectics (PC1, PC2, PC3, and PC4) in different molar ratios (3:1, 3:2, 1:1, and 3:4 respectively) were prepared by simple solvent evaporation method. Difference in dislocation density and strain value of the eutectics were observed, and the maximum strain value of PC1 might be due to the highest deformation activity compared to PC2, PC3, and PC4. Carbonyl-thiazolidine or carboxyl-pyridine weak bond formation might be the reason of producing eutectics of PGZ-CA rather than cocrystal with a docking score of – 2.2 Kcal/M. Likewise, lowest particle size was found with PC1 rather than that of pure PGZ and other eutectics. PC1 demonstrated highest dissolution of drug (68 %) rather than other eutectics (54 to 61 %) and PGZ (44 %) after 360 min.