Synthesis, characterization and biological applications of substituted indolo[2,1-b]quinazolin-12(6H)-one based rhenium(I) organometallic compounds

Abstract

The Re(I) organometallic compounds [(Re(CO)₃L^1-6 )Cl], where Ligand(L) = Tryptanthrin derivatives were prepared and characterized by various spectroscopic techniques. To assess the binding capacities and binding manner, tests of Calf thymus DNA under the impact of organometallic complexes were conducted using absorption titration and viscosity measuring techniques. Data from the research mentioned above point to an intercalation type of binding, which was verified by the docking study. Swiss ADME tools carried out an ADME study. The work focuses on computing the molecular orbital energies for the synthesized compounds using the density functional theory (DFT). The compounds were tested against the MCF-7 cell line to determine their anticancer effects. It was observed that their IC₅₀ values were equivalent to those of the standard medication, indicating that they had a similar antiproliferative impact.