Brain Targeted Drug Delivery System of Carmustine: Design, Development, Characterization, in-vitro, ex-vivo evaluation and in-vivo pharmacokinetic study

Abstract

The treatment of glioma still presents a difficult task. Carmustine is a drug which is used in the treatment of glioma. Flexible liposomes embedded in-situ thermoreversible nasal gel preparations of carmustine were determined for in-vitro carmustine release, ex-vivo carmustine permeation, along carmustine release kinetics study. The epithelial layer for nasal tissue remained confirmed to be intact and unharmed according to the histological analysis. Intranasal administration of optimized flexible liposomes embedded in-situ nasal gel of carmustine showed greater C_max (~two-fold), AUC_0→t (~three-fold), AUC_0→∞ (~six-fold), & decreased T_max (1 h) values in the brain, as compared to marketed intravenous injection of carmustine. The present study demonstrates the flexible liposome-embedded mucoadhesive in-situ nasal gel of carmustine improves brain targeted of carmustine by the nasal delivery system and would be a reliable and impactful carmustine delivery system in the treatment of glioma.