Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds

Uroš Grošelj; Marija Gršič; Anže Meden; Damijan Knez; Marko Jukič; Jurij Svete; Stanislav Gobec

doi:10.17344/acsi.2023.8460

Authors

Uroš Grošelj a. University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000 Ljubljana https://orcid.org/0000-0002-5186-9879
Marija Gršič
Anže Meden https://orcid.org/0000-0003-3594-6579
Damijan Knez https://orcid.org/0000-0001-9917-1384
Marko Jukič https://orcid.org/0000-0001-6083-5024
Jurij Svete https://orcid.org/0000-0003-3339-3595
Stanislav Gobec https://orcid.org/0000-0002-9678-3083

DOI:

https://doi.org/10.17344/acsi.2023.8460

Abstract

Synthesis and anticholinesterase activity of 18 previously unpublished indole- and tryptophan-derived compounds are disclosed. These sp³-rich compounds containing an indole structural unit exhibit selective submicromolar inhibition of human butyrylcholinesterase (hBChE). The structures of the newly synthesized compounds were confirmed by ¹H and ¹³C NMR, IR spectroscopy, and high-resolution mass spectrometry.

Author Biography

Uroš Grošelj, a. University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000 Ljubljana

Chair of Organic chemistry

Synthesis and Cholinesterase Inhibitory Activity of Selected Indole-Based Compounds

Authors

DOI:

Abstract

Author Biography

Uroš Grošelj, a. University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000 Ljubljana

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