Synthesis, Crystal Structures and Urease Inhibition of Copper(II) and Cobalt(III) Complexes Derived from (((2-(Pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol

Abstract

Three copper(II) and cobalt(III) complexes, [CuL(dca)]_n (1), [CuL(N₃)]_n (2) and [CoL(N₃)₂(DMF)] (3), where L is the monoanionic form of the Schiff base (((2-(pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol (HL), and dca is dicyanamide, have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, as well as single crystal X-ray diffraction. The Cu atoms in complexes 1 and 2 are in square pyramidal coordination, with the phenolate O, imino N and pyrrolidine N atoms of the Schiff base ligand, and one terminal N atom of dca or azide ligand in the basal plane, and with the other terminal N atom of dca or azide ligand at the apical position. Complexes 1 and 2 inhibit the Jack bean urease with IC₅₀ values of 0.25±0.14 and 0.32±0.15 μmol L^–1, respectively. Complex 3 show weak activity on Jack bean urease with percentage inhibition of 37%.