Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity

Authors

  • Amira E. M. Abdallah Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt http://orcid.org/0000-0002-6773-3634
  • Rafat M Mohareb Department of Chemistry, Faculty of Science, Cairo University, Giza 12614, A. R. Egypt
  • Maher H. E. Helal Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt
  • Mariam M Abd Elkader Department of Chemistry, Faculty of Science, Helwan University, Ain Helwan, Cairo-11795, A. R. Egypt

DOI:

https://doi.org/10.17344/acsi.2022.7893

Keywords:

Tetrahydrobenzo[b]pyran, thiophene, pyridine, anti-proliferative

Abstract

Many new cyclized pyran systems with a potential anti-cancer activity were 13 designed and prepared. Pyran systems showed high reactivity to various chemical 14 reagents. 24 products of the prepared compounds were chosen and tested in (mM) as 15 respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were 16 the widely effective compounds against the three cancer cell lines including A-549 17 (Lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (Gastric cancer) 18 compared to the standard reference control foretinib.

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Published

31.05.2023

Issue

Vol. 70 No. 2 (2023): Acsi

Section

Organic chemistry

License

Copyright (c) 1970 Amira E. M. Abdallah, Rafat M Mohareb, Maher H. E. Helal, Mariam M Abd Elkader

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License