Syntheses, Structures and Insulin-Like Activity of Two Oxidovanadium(V) Complexes with Similar Nicotinohydrazone Ligands

Authors

  • Gao-Qi Zhou Ningbo University
  • Xiao-Yang Qiu Ningbo University
  • Shu-Juan Liu Ningbo University
  • Chu-Yi Wang Ningbo University

DOI:

https://doi.org/10.17344/acsi.2022.7605

Keywords:

Nicotinohydrazone ligand, oxovanadium complex, crystal structure, thermal property, insulin-like activity

Abstract

Two new oxidovanadium(V) complexes, [VOL1(HQ)] (1) and [VOL2(SAH)] (2), were prepared by the reaction of [VO(acac)2] (where acac = acetylacetonate) with N'-(3-ethoxy-2-hydroxybenzylidene)nicotinohydrazide (H2L1) and 8-hydroxyquinoline (HHQ), and N'-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L2) and salicylhydroxamic acid (HSAH), respectively, in methanol. Crystal and molecular structures of the complexes were determined by elemental analysis, infrared spectroscopy and single crystal X-ray diffraction. The V atoms in both complexes are in octahedral coordination. Thermal stability of the complexes was studied. Both complexes can decrease the blood glucose level in alloxan-diabetic mice, but the blood glucose level in the treated normal mice was not altered.

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Author Biography

Chu-Yi Wang, Ningbo University

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Published

26.09.2022

Issue

Vol. 69 No. 3 (2022)

Section

Inorganic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License