A Novel Method for the One-pot Five-component Synthesis Highly Functionalized Pyranopyrazoles Catalyzed by CuI Nanoparticles

Authors

  • Javad Safaei-Ghomi Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 51167, Kashan, I. R. Iran
  • Abolfazl Ziarati Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 51167, Kashan, I. R. Iran
  • Mehrnoush Tamimi Department of Chemistry, Qom Branch, Islamic Azad University, Qom, I. R. Iran

Keywords:

Pyranopyrazoles, one pot, five-component reaction, in situ preparation, CuI nanoparticles.

Abstract

A novel one-pot, five-component reaction for the synthesis of highly functionalized pyranopyrazoles from acid chlorides, Meldrum's acid, hydrazine hydrate, aromatic aldehydes and malononitrile in the presence of catalytic amount of CuI nanoparticles in aqueous media is reported. This method provides several benefits such as in situ preparation of beta-ketoester, mild reaction conditions, and environmentally friendly, waste-free and simple work-up procedure with excellent yields. The catalyst could be recovered and reused for several times with almost consistent catalytic activity.

 

Author Biography

Javad Safaei-Ghomi, Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 51167, Kashan, I. R. Iran

 

 

Downloads

Published

28.10.2013

Issue

Vol. 60 No. 2 (2013)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License