Synthesis, Crystal Structures and Urease Inhibition of 4-Bromo-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide and Its Dinuclear Copper(II) Complex

Authors

  • Hui Zhao Wuhan Textile University
  • Xiu-Rui Liu Wuhan Textile University
  • Xue Wang Wuhan Textile University
  • Jing Hu Hubei Drug Administration
  • Ya-Jun Cai Wuhan Textile University
  • Qi-An Peng Wuhan Textile University

DOI:

https://doi.org/10.17344/acsi.2021.6781

Keywords:

Benzohydrazone, copper complex, crystal structure, biological activity

Abstract

A new dinuclear copper(II) complex [Cu2(μ-Br)2L2]·0.5MeOH with the benzohydrazone ligand 4-bromo-N'-(1-(pyridin-2-yl)ethylidene)benzohydrazide (HL) has been synthesized and characterized by elemental analysis, IR and UV-Vis spectroscopic studies. Single crystal structures of the complex and the benzohydrazone compound were studied. The Cu atoms in the complex are coordinated by two benzohydrazone ligands and two Br bridging groups, forming square pyramidal coordination. The complex has good inhibitory activity on Jack bean urease, with IC50 value of 1.38 μmol·L-1.

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Published

15.12.2021

Issue

Vol. 68 No. 4 (2021)

Section

Inorganic chemistry

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Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License