Synthesis, Characterization and Crystal Structures of Fluoro-Substituted Aroylhydrazones with Antimicrobial Activity

Authors

  • Fu-Ming Wang Dezhou University
  • Li-Jie Li Beijing Institute of Technology
  • Guo-Wei Zang Beijing Institute of Technology
  • Tong-Tong Deng Beijing Institute of Technology
  • Zhong-Lu You Liaoning Normal University

DOI:

https://doi.org/10.17344/acsi.2020.6051

Keywords:

Aroylhydrazone, antimicrobial activity, synthesis, X-ray diffraction

Abstract

A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

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Published

15.09.2021

Issue

Vol. 68 No. 3 (2021)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License