Active Forces of Myosin Motors May Control Endovesiculation of Red Blood Cells

Authors

  • Samo Penič Faculty of Electrical Engineering, University of Ljubljana http://orcid.org/0000-0002-1175-6108
  • Miha Fošnarič Faculty of Health Sciences, University of Ljubljana
  • Luka Mesarec Faculty of Electrical Engineering, University of Ljubljana
  • Aleš Iglič Faculty of Electrical Engineering, University of Ljubljana Faculty of Medicine, University of Ljubljana
  • Veronika Kralj-Iglič Faculty of Health Sciences, University of Ljubljana Faculty of Electrical Engineering, University of Ljubljana

DOI:

https://doi.org/10.17344/acsi.2020.5863

Keywords:

Myosin generated active forces, Monte Carlo simulations, endovesiclulation, intrinsic curvature, red blood cell

Abstract

By using Monte Carlo (MC) simulations, we have shown that the active forces generated by (NMIIA) motor domains bound to F-actin may partially control the endovesiculation of the red blood cell (RBC) membrane. The myosin generated active forces favor pancake-like (torocyte) RBC endovesicles with a large flat central membrane region and a bulby periphery. We suggest that the myosin generated active forces acting on the RBC membrane in the direction perpendicular to the membrane surface towards the interior of the RBC may influence also other RBC shape transformations and the stability of different types of RBC shapes and should be therefore considered in the future theoretical studies of the RBC vesiculation and shape transformations.

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Published

15.06.2020

Issue

Vol. 67 No. 2 (2020)

Section

Biomedical applications

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License