Room Temperature Synthesis and Characterization of Novel Bi(III) Complex with 2-Amino-3-Carbomethoxy-4,5,6,7-Tetrahydrobenzo[B]Thiophene as Potential Antimicrobial Agent

Authors

  • Emmanuel Fondjo Sopbué Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon
  • Désire André Siéwé Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon
  • Jean-de-Dieu Tamokou Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon
  • Steve Endeguele Ekom Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon
  • Sorel Kamal Dimo Djeukoua Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Republic of Cameroon
  • Giscard Doungmo Institut für Anorganische Chemie, Christian-Albrechts-Universität zu Kiel, Max-Eyth-Str. 2, 24118 Kiel, Germany
  • Mallory E. Walters Department of Chemistry, Carleton University, 1125 Colonel Δby Drive K1S 5B6, Ottawa, Canada +1-613-520-260 Ext 3122
  • Appolinaire Tsopmo Department of Chemistry, Carleton University, 1125 Colonel Δby Drive K1S 5B6, Ottawa, Canada +1-613-520-260 Ext 3122
  • Peter F. W. Simon Polymer Chemistry Laboratory, Faculty of Live Sciences, Rhine-Waal University of Applied Sciences, Campus Kleve, Marie-Curie Strasse 1, D-47533 Kleve, Germany
  • Jules Roger Kuiate Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067 Dschang, Republic of Cameroon

DOI:

https://doi.org/10.17344/acsi.2019.5365

Keywords:

Room temperature synthesis, antimicrobial, complexation reaction, 2-aminothiophene, bismuth

Abstract

A novel bismuth(III) complex with 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) as a ligand have been synthesized. The novel complex was characterized on the basis of its IR, NMR, elemental analysis and MS spectral data. It was found that the ligand behaves as a monodentate chelating agent and bonds to the metal ion through the nitrogen atom of the amino group to form the [BiIII(ACTT)6]Cl3 complex. The new complex compound displayed significant antimicrobial activity (MIC = 8–32 μg/mL) against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Shigella flexneri, Candida albicans, Candida tropicalis and Cryptococcus neoformans.

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Published

20.03.2020

Issue

Vol. 67 No. 1 (2020)

Section

Inorganic chemistry

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Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License