Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents

Authors

  • Mamdouh Sofan Department of Chemistry, Faculty of Science, Damietta University, New Damietta 34517, Egypt
  • Wafaa Hamama Chemistry Department, Faculty of Science, Mansoura University, Egypt
  • Ibrahim Ibrahim EL-Hawary Chemistry Department, Faculty of Science, Damietta University, Egypt
  • Ismail Taha Ibrahim Hot Laboratories Center, Atomic Energy Authority, Cairo, Egypt
  • Hanafi Hassan Zoorob Chemistry Department, Faculty of Science, Mansoura University, Egypt

DOI:

https://doi.org/10.17344/acsi.2019.4980

Keywords:

Nicotinonitrile, thiopyrano[2, 3-b]pyridine, cytototoxic activity, ascites tumor

Abstract

The new thiopyrano[2,3-b]pyridines 4–9 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most potent activity, more than 6 and 8. The compound 5 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent. In the light of this result, the labeled 125I-compound 5 (125I-TP5) was prepared and its cytotoxicity against ascites tumor in mice has been evaluated. The results show that compound 5 (TP5) may be potentially used as a radiopharmaceutical for tumor diagnosis when labeled with 125I.

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Published

18.09.2019

Issue

Vol. 66 No. 3 (2019)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License