Synthesis, Anti-inflammatory and Antioxidant Activities of Novel 3H-Thiazolo[4,5-b]pyridines

Authors

  • Taras I. Chaban Danylo Halytsky Lviv National Medical University
  • Volodymyr V. Ogurtsov Danylo Halytsky Lviv National Medical University
  • Vasyl S. Matiychuk Ivan Franko National University of Lviv
  • Ihor G. Chaban Danylo Halytsky Lviv National Medical University
  • Inna L. Demchuk Danylo Halytsky Lviv National Medical University
  • Ihor A. Nektegayev Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.17344/acsi.2018.4570

Keywords:

thiazolo[4, 5-b]pyridines, synthesis, anti-inflammatory activity, antioxidant activity

Abstract

5-Hydroxy-7-methyl-3H-thiazolo[4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C5 and C6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

Author Biographies

Taras I. Chaban, Danylo Halytsky Lviv National Medical University

Department of General, Bioinorganic, Physical and Colloidal Chemistry; Associate professor, PhD

Volodymyr V. Ogurtsov, Danylo Halytsky Lviv National Medical University

Head of Department General, Bioinorganic, Physical and Colloidal Chemistry; Associate professor, PhD

Vasyl S. Matiychuk, Ivan Franko National University of Lviv

Department of Organic Chemistry; Professor, PhD, DSc 

Ihor G. Chaban, Danylo Halytsky Lviv National Medical University

Head of Department Pharmaceutical Chemistry FPGE;Associate professor, PhD

Inna L. Demchuk, Danylo Halytsky Lviv National Medical University

Department of Pharmaceutical, Organic and Bioorganic Chemistry; Associate professor, PhD

Ihor A. Nektegayev, Danylo Halytsky Lviv National Medical University

Department of Pharmacology; Assistant professor, PhD

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Published

15.02.2019

Issue

Vol. 66 No. 1 (2019)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License