Solvent-free synthesis of dihydropyrano [3,2-c]chromene and biscoumarin derivatives using magnesium oxide nanoparticles as a recyclable catalyst

Abstract

In these research, an efficient one pot approach for the synthesis of dihydropyrano[3,2-c]chromenes and biscoumarins as important heterocyclic compounds with pharmacological and biological properties have been prepared using nanocrystalline magnesium oxide. Magnesium oxide nanoparticles were significantly catalyzed three component reaction of aldehydes, ethyl cyanoacetat and 4-hydroxycoumarin in high yields and short reaction times under solvent-free conditions. Nano magnesium oxide as an efficient, available and cheap heterogeneous nanoparticles were used for several times in the synthesis of dihydropyrano [3,2-c]chromenes and biscoumarins.