Vanadium Complex Derived from N’-(3-Bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide: Synthesis, Crystal Structure and Biological Activity

Abstract

Reaction of VO(acac)₂ with N’-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H₂L) in methanol afforded a new mononuclear vanadium(V) complex, [VOL(OMe)(MeOH)]. Structure of the complex has been characterized by physico-chemical methods and single-crystal X-ray diffraction. The complex crystallizes as the monoclinic space group P2₁/c, with unit cell dimensions a = 13.1345(10) Å, b = 18.6279(14) Å, c = 7.8983(8) Å, β = 90.248(2)º, V = 1932.4(3) ų, Z = 4, R₁ = 0.0963, wR₂ = 0.2213, S = 1.113. X-ray analysis indicated that the V atom in the complex is in octahedral coordination. The insulin-like activity of the complex was studied.