A Rapid One-pot Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Using Brřnsted-acidic

Authors

  • Roghayeh Hossein Nia Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • Manouchehr Mamaghani Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • Khalil Tabatabaeian Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • Farhad Shirini Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • Mehdi Rassa Department of Biology, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

Keywords:

6-amino-2-(methylthio)pyrimidin-4(3H)-one, ethylcyanoacetate, meldrum’s acid, pyrido[2, 3-d]pyrimidine, ionic liquid, one-pot three-component reaction.

Abstract

Pyrido[2,3-d]pyrimidine derivatives were synthesized regioselectivly in good to high yields by one-pot three-component condensation of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, aromatic aldehydes and ethylcyanoacetate or meldrum’s acid using 1,2–dimethyl-N-butanesulfonic acid imidazolium hydrogen sulfate ([DMBSI]HSO4) Brřnsted-acidic ionic liquid as catalyst. Solvent-free mild reaction conditions, short reaction times, easy work-up, and reusability of the catalyst are the main advantages of this protocol.

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Published

13.01.2014

Issue

Vol. 60 No. 4 (2013)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License