In Silico Study of Plant Polyphenols' Interactions with VP24–Ebola Virus Matrix Protein

Authors

  • Sebastian Pleško 1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia
  • Helena Volk 1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia
  • Miha Lukšič 1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia
  • Črtomir Podlipnik 1Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia

DOI:

https://doi.org/10.17344/acsi.2015.1505

Keywords:

Ebola virus, VP24, KPNA5, STAT1, plant polyphenols, molecular docking

Abstract

The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6–tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies.

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Published

29.04.2015

Issue

Vol. 62 No. 3 (2015)

Section

Biochemistry and molecular biology

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License