Scandium(III) Triflate Catalyzed 1,4-Addition of Cyano Group to Enones Using Tetraethylammonium Cyanide as the Cyanide Source

Authors

  • Samikannu Ramesh Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem – 636 011, Tamil Nadu, India
  • Appaswami Lalitha Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem – 636 011, Tamil Nadu, India

Keywords:

Scandium(III) triflate, tetraethylammonium cyanide, 1, 4-addition, β-cyanoketone, chalcones

Abstract

A novel and practical method has been developed for the synthesis of β-cyanoketones using tetraethylammonium cyanide (Et4NCN, TEACN) / Sc(III) triflate and chalcones without the liberation of toxic HCN gas. Availability, safety, easy handling of the reagents, mild conditions of the reaction and high yields, make this method an attractive protocol for the direct synthesis of cyano substituted 1,4-adducts from enones.

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Published

06.11.2013

Issue

Vol. 60 No. 3 (2013)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License