First Direct Isolation of Stable α-Form Crystals of Mirabegron, a Selective β3–Adrenoceptor Agonist
Keywords:β3-adrenoceptor agonist, Mirabegron, polymorphism, polymorphic transformation
An efficient and scalable method for the direct isolation of stable α-form crystals of mirabegron (1) is developed. The developed method negates transformation of metastable β-form crystals into α-form crystals thereby overcome the limitations of reported methods and avoids additional processing steps during its manufacture. The developed method directly provides stable α-form crystals of Mirabegron (1) with yield of around 84 % and purity of >99.77% by HPLC in a single step.
Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License